Experiment 928157
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | DANKS,MK: SCHMIDT,CA: DENEKA,DA: BECK,WT:. (1989). INCREASED ATP REQUIREMENT FOR ACTIVITY OF AND COMPLEX FORMATION BY DNA TOPISOMERASE II FROM HUMAN LEUKEMIC CCRF-CEM CELLS SELECTED FOR RESISTANCE TO TENIPOSIDE.. 1(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | LEUKEMIA CELLS RESISTANT TO TENIPOSIDE ARE USED. TOPOISOMERASE II ACTIVITY AND ABILITY TO FORM STABLE COMPLEXES WITH DNA(IN PRESENCE OF TENIPOSIDE) ARE BOTH DECREASED 40-80% IN RESISTANT CELLS. THE RESISTANT CELLS REQUIRED 2-8 TIMES THE CONCENTRATION OF ATP TO ACHIEVE HALF-MAXIMAL STIMULATION OF UNKNOTTING COMPARED TO SENSITIVE CELLS. TETRALITHIUM SALT OF 5'-ANENYLIMIDODIPHOSPHATE, A NON-HYDROLYZABLE ANALOG OF ATP IS AS EFFECTIVE AS ATP IN PROMOTING TENIPOSIDE-STABILIZED DNA-TOPOISOMERASE II COMPLEX FORMATION. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CELL CULTURE |
| Dose expression | CONC USED |