Experiment 928159
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | HU,E: KO,R: KODA,R: ROSEN,P: JEFFERS,S: SCHOLTZ,M: MUGGIA,F:. (1990). PHASE I TOXICITY AND PHARMACOLOGY STUDY OF TRIMETHYLCOLCHICINIC ACID IN PATIENTS WITH ADVANCED MALIGNANCIES.. 26(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | 19 PATIENTS WERE ENTERED IN A PHASE I STUDY: 7 HAD BREAST CANCER, 3 LUNG, 2 OVARIAN, 1 EACH HAD MELANOMA, LYMPHOMA, KAPOSIS SARCOMA, RENAL CELL, PROSTATE, COLON, FALLOPIAN TUBE CARCINOMAS. DOSE (5-7 MG/SQ.M.) GIVEN DAILY FOR 5 DAYS EVERY 3 WKS. COURSES OF TREATMENT NUMBERED 1-8. MAJOR TOXICIITIES WERE MYELOSUPPRESSION AND MUCOSITIS. PARITAL RESPONSE OCCURRED IN ONE LYMPHOMA PATIENT; STABILIZATION WAS NOTED IN ONE PATIENT EACH WITH PROSTATIC AND OVARIAN CANCER. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | WEAK ACTIVITY |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |