Experiment 928351
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | CHATELUT,E: CHEVREAU,C: BLANCY,E: LEQUELLEC,A: CANAL,P: ROCHE,H: HOUIN,G: BUGAT,R:. (1990). PHARMACOKINETICS AND TOXICITY OF TWO MODALITIES OF ETOPOSIDE INFUSION IN METASTATIC NON-SMALL-CELL LUNG CARCINOMA.. 26(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | 19 PATIENTS WITH METASTIC NON SMALL-CELL LUNG CARCINOMA USED IN THIS PHARMOKINETIC STUDY. MEAN DISTRIBUTION HALF-LIFE WAS 1.26 HRS AND MEAN ELIMINATION HALF-LIFE WAS 9.17 HRS. STEADY STATE PLASMA CONCENTRATION WAS OBTAINED BETWEEN 12 AND 24 HRS. MEAN TOTAL BODY CLEARANCE WAS EITHER 16.3 ML/MIN/SQ.M. OR 18.0 ML/MIN/SQ.M. DEPENDING ON THE DOSE. PATIENTS WERE GIVEN A DOSE OF EITHER 360 OR 120 MG/SQ.M. FOR 3 CONSECUTIVE DAYS. 41 CYCLES WERE GIVEN. IN ADDITION 80 MG/SQ.M. OF CIS-DIAMMINEDICHLOROPLATINUM WERE GIVEN TO PATIENTS ON DAY ONE. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |