Experiment 929007
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | MARSHALL,ME: BUTLER,K: HERMANSEN,D:. (1990). TREATMENT OF HORMONE-REFRACTORY STAGE D CARCINOMA OF PROSTATE WITH COUMARIN (1,2-BENZOPYRONE) AND CIMETIDINE: A PILOT STUDY.. 17(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | 14 PATIENTS WITH PROSTATE CANCER AND BONE METASTASES WERE TREATED IN THIS STUDY. PATIENTS WERE GIVEN COUMARIN FOR 14 DAYS; ON DAY 15, CIMETIDINE 300 MG 4 TIMES DAILY WAS ADDED. BOTH DRUGS WERE CONTINUED UNTIL PROGRESSION OF DISEASE. THERE WAS NO EVIDENCE OF TUMOR REGRESSION IN ANY PATIENT. SEVERAL PATIENTS HOWEVER REPORTED SYMPTOMATIC IMPROVEMENT. 3 PATIENTS SHOWED MARKED IMPROVEMENT IN BONE PAIN. |
| Dose amount | 100.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |