Experiment 929550
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | ACETI,A: BONINCONTRO,A: CAMETTI,C: CELESTINO,D: LERI,O:. (1990). ELECTRICAL CONDUCTIVITY OF HUMAN ERYTHROCYTES INFECTED WITH PLASMODIUM FALCIPARUM AND ITS MODIFICATION FOLLOWING QUININE THERAPY.. 84(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | A CEREBRAL MALARIA PATIENT WAS TREATED WITH QUININE WHILE MEMBRANE CONDUCTIVITY OF ERYTHROCYTES WAS MEASURED. CONDUCTIVITY FELL DURING TREATMENT TO THE LEVEL OF NORMAL ERYTHROCYTES. THIS IS SAID TO BE BECAUSE A PARASITE-INDUCED INCREASE IN MEMBRANE PERMEABILITY (=CONDUCTIVITY) IS COUNTERACTED BY QUININE. THIS PROHIBITS THE ENTRY OF PHYSIOLOGICALLY RELEVANT SUBSTANCES TO THE CELL AND INHIBITS PARASITE GROWTH. DOSING WAS EVERY 8 HOURS. |
| Dose amount | 10.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |