Experiment 929756
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | SOWUNMI,A: SALAKO,A: LAOYE,OJ: ADEROUNMU,AF:. (1990). COMBINATION OF QUININE, QUINIDINE, AND CINCHONINE FOR THE TREATMENT OF ACUTE FALCIPARUM MALARIA: CORRELATION WITH THE SUSCEPTIBILITY OF PLASMODIUM FALCIPARUM TO THE CINCHONA ALKALOIDS IN VITRO.. 84() |
| Amount utilized | |
| Compound isolated | |
| Disease | 13 PATIENTS PARTICIPATED IN A RANDOMIZED, OPEN TRIAL OF LA40221, A DRUG CONTAINING EQUAL PARTS OF QUININE, QUINIDINE AND CINCHONINE. DOSING WAS ONCE EVERY 8 HOURS FOR 7 DAYS. PARASITEMIA CLEARED IN 29 HRS, FEVER IN 10 HRS. THIS WAS COMPARABLE TO A CONTROL GROUP TREATED WITH QUININE ONLY. MINOR GASTROINTESTINAL SIDE EFFECTS WERE NOTED, BUT NOT CINCHONISM. NO OTHER MAJOR SIDE EFFECTS WERE FOUND. ANOTHER GROUP RECEIVED ALKALOID DOSES OF 166.7 MG WITHOUT SUBSTANTIAL DIFFERENCE IN RESULTS. |
| Dose amount | 133.3 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |