Experiment 932535

Worktypes

PHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

CAMPTOTHECIN

Details

PropertyValue
Pharmacology
TOPOISOMERASE I INHIBITION
OrganismEmpty organism
CitationKINGSBURY,WD: BOEHM,JC: JAKAS,DR: HOLDEN,KG: HECHT,SM: GALLAGHER,G: CARANFA,MJ: MC CABE,FL: FAUCETT,LF: JOHNSON,RK: HERTZBERG,HP:. (1991). SYNTHESIS OF WATER-SOLUBLE (AMINOALKYL) CAMPTOTHECIN ANALOGUES: INHIBITION OF TOPOISOMERASE I AND ANTITUMOR ACTIVITY.. 34(1)
Amount utilized
Compound isolated
DiseaseCONCENTRATION PRODUCED 50% DNA CLEAVAGE.
Dose amount0.82 MICROMOLS
Number2
Qualitative resultACTIVE
Dose expressionCONC USED