Experiment 933692
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRACECAL |
| Organism | Empty organism |
| Citation | YAGI,T: MIYAWAKI,Y: NISHIKAWA,A: HORIYAMA,S: YAMAUCHI,K: KUWANO,S:. (1990). PROSTAGLANDIN E2-MEDIATED STIMULATION OF MUCUS SYNTHESIS AND SECRETIN BY RHEIN ANTHRONE, THE ACTIVE METABOLITE OF SENNOSIDES A AND B, IN THE MOUSE COLON.. 42(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | DECREASED H2O & NA+ ABSORPTION AND INCREASED K+ NET SECRETION. INDOMETHACIN PRETREATMENT DIMINISHED EFFECTS EXCEPT ON K+. MUCUS SECRETION WAS MARKEDLY ENHANCED AND ALSO SUPPRESSED BY INDOMETHACIN. EFFECTS OF PGE2 SIMILAR TO RHEIN ANTHRONE. |
| Dose amount | 6.24 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | DOSE |