Experiment 938575
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Escherichia coli (ENTEROBACTERIACEAE) |
| Citation | CLOT,J: ANDARY,M:. (1990). EFFECT IN VITRO OF A BACTERIAL EXTRACT (OM-89) ON INTERLEUKIN 1 AND INTERLEUKIN 2 PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS FROM HEALTHY SUBJECTS AND RHEUMATOID ARTHRITIS PATIENTS.. 12(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC) WERE OBTAINED FROM HEALTHY VOLUNTEERS AND RHEUMATOID ARTHRITIS (RA) PATIENTS (SUFFERING FROM CLASSICAL RA). OM-89 INDUCED A SLIGHT INCREASE OF IL-2 PRODUCTION WHEN ADDED TO PHA-STIMULATED PBMC FROM NORMAL SUBJECTS. SUPERNATANTS FROM RA PATIENTS CONTAINED SIGNIFICANTLY LESS IL-2 THAN THOSE FROM NORMAL SUBJECTS. BUT IN THE PRESENCE OF OM-89 AT 500 AND 1000 MCG/ML, THE IL-2 PRODUCTION OFRA PBMC WAS IN THE SAME RANGE AS THAT OF NORMAL SUBJECT PBMC. |
| Dose amount | 500.0 MCG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | ML |
| Dose expression | CONC USED |
| Extract | CULTURE FILTRATE |