Experiment 938583
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | EIRAS,G: HASHEM,H: ZEEVI,A: WONG,L: DUQUESNOY,RJ: BURCKART,GJ:. (1991). THE IMMUNOSUPPRESSIVE ACTIVITY OF THE ALDEHYDIC TRANSFORMATION OF CYCLOSPORINE ON ALLOREACTIVE T-CELLS.. 31(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | CYCLOSPORINE ACTS TO INHIBIT THE PROLIFERATION OF CYTOTOXIC T-LYMPHOCYTES THRU THE INHIBITION OF IL-2 SYNTHESIS. THE AUTHORS CONCLUDED THAT THE STRUCTURAL MODIFICATION FORMED BY METABOLISM OF CYCLOSPORINE TO THE ALDEHYDIC STRUCTURE ELIMINATES ITS ANTIPROLIFERATIVE ACTIVITY ON T-LYMPHOCYTES. THE CONCENTRATION OF CYCLOSPORINE REQUIRED TO INHIBIT PROLIFERATION BY 50% IN T CELLS PROPAGATED FROM A HEART BIOPSY SPECIMEN WAS 50 NG/ML. |
| Dose amount | 150.0 NG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | ML |
| Dose expression | DOSE |