Experiment 941769

Compounds isolated

Details

PropertyValue
Pharmacology
OrganismEmpty organism
CitationSHARKIS,SJ: JONES,RJ: BELLIS,ML: DEMETRI,GD: GRIFFIN,JD: CIVIN,C: MAY,WS:. (1990). THE ACTION OF BRYOSTATIN ON NORMAL HUMAN HEMATOPOIETIC PROGENITORS IS MEDIATED BY ACCESSORY CELL RELEASE OF GROWTH FACTORS.. 76(4)
Amount utilized
Compound isolated
DiseaseCONCENTRATIONS OF 100 PICOMOLAR TO 1 NANOMOLAR OF COMPOUND STIMULATED COLONY FORMATION NOT IN SINGLE CELL CULTURES BUT IN MULTICELLULAR CULTURES, WITH EFFICIENCY OF CLONING INCREASING WITH NUMBER OF INITIAL CELLS. RESULTS ARE CONSISTENT WITH HYPOTHESIS THAT THE COMPOUND HAS STIMULATORY EFFECT ON ACCESSORY CELL POPULATIONS TO PRODUCE EITHER INTERLEUKIN-3 OR GRANULOCYTE-MACROPHAGE COLONY-STIMULANTING FACTOR.
Dose amountVAR
Number1
Qualitative resultACTIVE
Dose expressionCONC USED