Experiment 945057

Worktypes

PHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

XESTOQUINONE

Details

PropertyValue
Pharmacology
INOTROPIC EFFECT POSITIVE
OrganismEmpty organism
CitationKOBAYASHI,M: NAKAMURA,H: KOBAYASHI,J: OHIZUMI,Y:. (1991). MECHANISM OF INOTROPIC ACTION OF XESTOQUINONE, A NOVEL CARDIOTONIC AGENT ISOLATED FROM A SEA SPONGE.. 257(1)
Amount utilized
Compound isolated
DiseaseEFFECT ANTAGONIZED BY VERAPAMIL OR NIFEDIPINE BUT NOT BY PRACTOLOL, CHLORPHENIRAMINE, CIMETIDINE, TETRODOTOXIN OR RESERPINE. EXTERNAL CA++ CONCENTRATION-CONTRACTILE RESPONSE CURVE SHIFTED TO LEFT. PEAK TENSION TIME & RELAXATION TIME DECREASED.
Dose amount2.0 MICROMOLS
Number1
Qualitative resultACTIVE
AnimalGUINEA PIG
Dose expressionED50