Experiment 949717
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Ecklonia kurome (ALARIACEAE) |
| Citation | NISHINO,T: AIZU,Y: NAGUMO,T:. (1991). THE RELATIONSHIP BETWEEN THE MOLECULAR WEIGHT AND THE ANTICOAGULANT ACTIVITY OF TWO TYPES OF FUCAN SULFATES FROM THE BROWN SEAWEED ECKLONIA KUROME.. 55(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | EFFFCT SEEN IN VARIOUS SUBFRACTIONS(DISTINCT MW'S) OF GIVEN TYPE OF COMPOUND. CONCENTRATION OF FRACTION SHOWED LINEAR RELATION WITH LOG OF CLOTTING TIME IN 3 ASSAYS: ACTIVATED PARTIAL THROMBOPLASTIN TIME, PROTHROMBINE TIME AND THROMBINE TIME. WITH REGARD TO THE FIRST ASSAY, ACTIVITY INCREASED WITH MW UP TO 30,000 AFTER WHICH IT FELL OFF. IN THE SECOND ASSAY, ACTIVITY WAS INDEPENDENT OF MW. IN THE THIRD, ACTIVITY PLATEAUED AT MW'S OF 50,000. |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |