Experiment 950420
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | OREDIPE,OA: WHITE,SL: GRZEGORZEWSKI,K: GAUSE,BL: CHA,JK: MILES,VA: OLDEN,K:. (1991). PROTECTIVE EFFECTS OF SWAINSONINE ON MURINE SURVIVAL AND BONE MARROW PROLIFERATION DURING CYTOTOXIC CHEMOTHERAPY.. 83(16) |
| Amount utilized | |
| Compound isolated | |
| Disease | SWAINSONINE AMELIORATED THE LETHALITY ASSOCIATED WITH THE ADMINISTRATION OF THE CHEMOTHERAPUTIC AGENTS METHOTREXATE, CYCLOPHOSPHAMIDE, DOXORUBICIN AND FLUOROURACIL WHEN ADMINISTERED AT THEIR LETHAL DOSES. LETHALITY OF THE AGENTS WAS DECREASED FROM 65% TO 0%, 90% TO 40%, 80% TO 0% AND 90% TO 20% RESPECTIVELY. SWAINSONINE WAS GIVEN FOR 10 CONSECUTIVE DAYS. |
| Dose amount | 20.0 MCG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | DAY |
| Dose expression | DOSE |