Experiment 950870
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | ARIOKA,M: HIRATA,A: TAKATSUKI,A: YAMASAKI,M:. (1991). BREFELDIN A BLOCKS AN EARLY STAGE OF PROTEIN TRANSPORT IN CANDIDA ALBICANS.. 137(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | A CONCENTRATION OF 2.5-10.0 MCG/ML REVERSIBLY INHIBITED TRANSPORT OF ACID PHOSPHATASE TO PERIPLASM IN STRAIN IAM4888 OF THE GIVEN ORGANISM. THIS WAS SHOWN BY THE ACCUMULATION IN TREATED CELLS OF AN APPARENT INTERMEDIATE GLYCOSYLATED SPECIES WHICH IN CONTROLS WAS REPLACED BY A HETEROGENEOUS GROUP OF HIGHLY GLYCOSYLATED MATURE ACID PHOSPHATASE. THIS SUGGESTS THAT TRANSPORT FROM ER TO GOLGI WAS INHIBITED. TREATED CELLS ALSO DEMONSTRATED ABERRANT INTRACELLULAR MEMBRANE STRUCTURES. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Dose expression | CONC USED |