Experiment 951050
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | JELLINCK,PH: MICHNOVICZ,JJ: BRADLOW,HL:. (1991). INFLUENCE OF INDOLE-3-CARBINOL ON THE HEPATIC MICROSOMAL FORMATION OF CATECHOL ESTROGENS.. 56(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE CONVERSION OF ESTRADIOL TO 2-OH ESTRADIOL WAS INCREASED IN MICROSOMAL PREPARATION FROM ANIMALS GIVEN SINGLE DOSE OF COMPOUND 20 HRS EARLIER. THE CONVERSION TO 4-OH ESTRADIOL WAS ALSO INCREASED. NADPH (NOT NADH) WAS REQUIRED. SKF-525A INHIBITED THESE CONVERSIONS IMPLYING THAT P-450 WAS INVOLVED. ETHIONINE ALSO INHIBITED THESE CONVERSIONS. WHEN THE COMPOUND WAS ADDED DIRECTLY TO THE MICROSOMAL PREPARATION, AN INHIBITION OF THESE CONVERSIONS WAS PARADOXICALLY SEEN. |
| Dose amount | 20.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | ANIMAL |
| Dose expression | DOSE |