Experiment 955563
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Nicotiana tabacum (SOLANACEAE) |
| Citation | BHIDE,SV: AMMIGAN,N: NAIR,UJ: LALITHA,VS:. (1991). CARCINOGENICITY STUDIES OF TOBACCO EXTRACT IN VITAMIN A-DEFICIENT SPRAGUE-DAWLEY RATS.. 51(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | EXTRACT WAS GIVEN DAILY FOR 21 MONTHS IN DMSO SOLVENT, TO TWO GROUPS OF ANIMALS, ONE MAINTAINED ON A VIT-A-SUFFICIENT DIET AND ONE ON A VIT-A-DEFICIENT DIET. TREATMENT WITH EXTRACT INCREASED PULMONARY AND HEPATIC BENZO[A]PYRENE HYDROXYLASE LEVELS OVER CONTROLS IN BOTH GROUPS. THE DEFICIENCY ANIMALS HAD SIGNIFICANTLY HIGHER HEPATIC AND LOWER PULMONARY LEVELS WHEN COMPARED TO SUFFICINECY ANIMALS. |
| Dose amount | 3.0 MG |
| Number | 5 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Extract | MECL2 EXT |