Experiment 955735
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | CZERWINSKI,M: MC LEMORE,TL: PHILPOT,RM: NHAMBURO,PT: KORZEKWA,K: GELBOIN,HV: GONZALEZ,FJ:. (1991). METABOLIC ACTIVATION OF 4-IPOMEANOL BY COMPLEMENTARY DNA-EXPRESSED HUMAN CYTOCHROMES P-450: EVIDENCE FOR SPECIES-SPECIFIC METABOLISM.. 51(17) |
| Amount utilized | |
| Compound isolated | |
| Disease | COMPOUND WAS METABOLIZED BY P450 TO A DNA-BINDING ADDUCT. THE EXTENT OF THE BINDING WAS ASSAYED IN SEVERAL CELL LINES OF THE GIVEN CELL, EACH INFECTED WITH VACCINIA VIRUS CARRYING CDNA FOR A GIVEN CYTOCHROME P450 FORM. 3 FORMS OF HUMAN P450(CYP1A2, CYP3A3 AND CYP3A4) OF TWELVE TESTED, AND ONE (CYP4B1) OF 2 RODENT FORMS TESTED PRODUCED METABOLITES WHOSE DNA BINDING WAS 20.8, 5 AND 180 TIMES THAT METABOLITE FROM CONTROL CELLS INFECTED WITH WILD TYPE VIRUS. |
| Dose amount | 1.0 MICROCURIES |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CELL CULTURE |
| Per unit | ML |
| Dose expression | CONC USED |