| Disease | 32 PATIENTS WITH RECURRENT OR RESIDUAL ASTROCYTOMAS WERE TREATED IN THIS PHASE 2 STUDY. PATIENTS RECEIVED EITHER 12 MG/M 2/DAY OR 15 MG/M 2/DAY FOR 5 DAYS WITH CYCLES BEING REPEATED EVERY 3 WEEKS.
OF THE PATIENTS TREATED 1 SHOWED A COMPLETE RESPONSE, 3 SHOWED PARTIAL RESPONSE, 2 WERE IMPROVED, 5 SHOWED STABLE DISEASE AND 21 SHOWED INCREASING DISEASE.
THE TOXICITIES EXPERIENCED BY PATIENTS INCLUDED NEUROTOXICITY, DEPRESSION, SUICIDAL IDEATIONS, HALLUCINATIONS, LETHARGY, CONFUSION, SEIZURES, VOMITING, NAUSEA AND FREQUENCY OF STOOLS. |