| Disease | A DOUBLE-BLIND, PARTIAL CROSSOVER STUDY ON THE THERAPEUTIC EFFECT OF YOHIMBINE HCL ON ERECTILE DYSFUNCTION WAS DONE IN 82 SEXUALLY IMPOTENT PATIENTS.
ALL PATIENTS UNDERWENT A MULTIFACTORIAL EVALUATION, INCLUDING DETERMINATION OF PENILE BRACHIAL BLOOD PRESSURE INDEX, CAVERNOSOGRAPHY, SACRAL EVOKED RESPONSE, TESTOSTERONE AND PROLACTIN DETERMINATION.
DEROGATIS SEXUAL DYSFUNCTION INVENTORY AND DAYTIME AROUSAL TEST WERE ALSO MEASURED. AFTER 1 MONTH OF TREATMENT WITH A MAXIMUM OF 42 MG ORAL YOHIMBINE HCL DAILY, 14% OF THE PATIENTS EXPERIENCED RESTORATION OF FULL AND SUSTAINED ERECTIONS.
20% REPORTED A PARTIAL RESPONSE TO THE THERAPY AND 65% REPORTED NO IMPROVEMENT. 3 PATIENTS REPORTED A POSITIVE PLACEBO EFFECT. MAXIMUM EFFECT TAKES 2-3 WEEKS TO MANIFEST ITSELF.
YOHIMBINE WAS ACTIVE IN SOME PATIENTS WITH ARTERIAL INSUFFICIENCY AND A UNILATERAL SACRAL REFLEX ARC LESION, AND IN 1 WITH LOW SERUM TESTOSTERONE LEVELS.
THE 34% RESPONSE WAS CLAIMED TO BE ENCOURAGING, PARTICULARLY IN A VETERANS ADMINISTRATION POPULATION PRESENTING WITH A HIGH INCIDENCE OF DIABETES AND VASCULAR PATHOLOGICAL CONDITIONS NOT FOUND IN REGULAR OFFICE PATIENTS.
ONLY A FEW AND BENIGN SIDE EFFECTS WERE RECORDED, WHICH MAKES THIS MEDICATION WORTH AN ATTEMPT, OFTEN AS A FIRST LINE OF TREATMENT, EVEN AT A DOSE OF 8 TABLETS (42 MG) DAILY. |