Experiment 958400
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | LI,L: ZHANG,YH: HUANG,GZ:. (1988). EFFECTS OF THE MAJOR FRACTIONS OF LEIGONGTENG ON THE REPRODUCTIVE ORGANS OF RATS.. 17(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | TOTAL "GLYCOSIDES", TOTAL TERPENOIDS (211 MG/KG) AND ESPECIALLY TOTAL ALKALOIDS, ALL AT 60% OF THE LD50, CAUSED DEGENERATIVE CHANGES IN THE SEMINIFEROUS TUBULES OF TESTES IN RATS. THE SPERMATOGENIC CELLS WERE DEGENERATED AND REDUCED IN NUMBER. SPERMATIDS AND SPERMS WERE MOST SUSCEPTIBLE AND SPERMATOGONIA MOST RESISTANT TO THE EXTRACT. THE DAMAGING EFFECTS WERE SIMILAR TO THOSE SEEN BY GOSSYPOL. THE FRACTIONS TESTED WERE LESS DELITERIOUS TO THE OVARIES. |
| Dose amount | 80.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | CHROMATOGRAPHIC FRACTION |
| Gender | MALE |