Experiment 958405
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | ZHOU,GY: ZHANG,BZ: WANG,ZY: LI,QY:. (1987). EFFECT OF TRIPTERYGIUM WILFORDII ON CHROMOSOME ABERRATIONS IN MICE.. 16(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | ADMINISTRATION OF THE EXTRACT TO MICE AT 15, 20 AND 25 MG/KG CAUSED CHROMOSOME ABERRATIONS, MAINLY BREAKAGE, IN 4.3, 5.9 AND 24.0% OF THE CELLS OBSERVED, RESPECTIVELY. BREAKAGE WAS THE MAJOR CHROMOSOME DEFECT CAUSED. EXTRACT CAUSED CHROMOSOME BREAKAGE(ONE- AND TWO-POINT) RATES OF 50.0, 61.7 & 56.8%, RESPECTIVELY. CYCLOPHOSPHAMIDE CAUSED CHROMOSOME ABERRATIONS IN 42.6% OF CELLS AND CHROMOSOME BREAKAGE IN 56.0%. |
| Dose amount | 15-25 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |