Experiment 958419
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | YANG,J: XU,JY: LI,LZ:. (1988). EFFECT OF ETHYL ACETATE EXTRACT OF TRIPTERYGIUM WILFORDII ON MICRONUCLEI FORMATION IN BONE MARROW CELLS OF MICE.. 23(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | DOSING WAS ONCE DAILY FOR 2 DAYS. IT INDUCED MICRONUCLEI FORMATION IN 10.0 AND 14.6% OF POLYCHROMATIC ERYTHROCYTES, RESPECTIVELY. THE RATES OF CYCLOPHOSPHAMIDE (60 MG/KG, IP) AND NORMAL SALINE WERE 18.5 AND 1.0%, RESPECTIVELY. THE EXTRACT WAS CONCLUDED TO BE MUTAGENIC AND THE EFFECT PEAKED AT 45 HOURS AFTER DOSING. |
| Dose amount | 200.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | ETOAC EXT |