Experiment 959958
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN UTERO |
| Organism | Empty organism |
| Citation | HUGHES,RN: BEVERIDGE,IJ:. (1991). BEHAVIORAL EFFECTS OF EXPOSURE TO CAFFEINE DURING GESTATION, LACTATION OR BOTH.. 13(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | MATERNAL DOSING AT ONE OR BOTH OF THE GESTATIONAL (26 OR 45 MG/KG/DAY) OR LACTATIONAL (25 OR 35 MG/KG/DAY) LEVELS REDUCED LOCOMOTOR ACTIVITY AND INCREASED DEFECATION FOR MALES AT 1,2,4 AND 6 MONTHS OF AGE. REARING DECREASED IN BOTH SEXES AT MATERNAL LACTATIONAL DOSING OF 25 MG/KG/DAY. THE NUMBER OF ANIMALS OF EITHER SEX WHO FAILED TO OR HAD INCREASED LATENCY TO EMERGE INTO BRIGHTLY LIT AREA INCREASED ON MATERNAL GESTATIONAL DOSE OF 26 MG/KG/DAY. WHEN EXPOSED DURING BOTH GESTATION AND LACTATION, ANIMALS SHOWED DECREASED LOCOMOTOR AND REARING ACTIVITIES, INCREASED LATENCY FOR EMERGENCE, AND AT 6 MO ONLY, INCREASED DEFECATION. |
| Dose amount | VAR |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |