Experiment 960174
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | JIANG,YS: ZHAO,SP:. (1987). ANALYSIS OF 15 CASES OF ACUTE RENAL FAILURE DIE TO TRIPTERGIUM WILFORDII POISONING.. 12(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS PAPER SUMMARIZES 15 CASES OF TRIPTERYGIUM WILFORDII POISONING REPORTED BETWEEN 1975 AND 1985 IN CHINA. ALL OF THE CASES REPORTED HAD NO PREVIOUS KIDNEY DISEASE. AFTER TAKING THE PLANT MATERIAL (UNPROCESSED ROOTS AND YOUNG BUDS) THERE WAS A DECREASE IN URINE OUTPUT, CESSATION OF URINE OUTPUT, SWELLING AND BLOOD IN THE URINE WHICH WAS OBSERVED IN ALL PATIENTS. IN 8 CASES DIURETICS WERE USED TO INCREASE URINATION. AMONG THE 15 PATIENTS, 6 WERE MALE AND 9 WERE FEMALE. THE OLDEST WAS 62 AND THE YOUNGEST WAS 18 WITH AN AVERAGE AGE OF 34.2 YEARS. THIRTEEN CASES WERE POISONED BY INTAKE OF ONE LARGE DOSE AND TWO CASES RESULTED FROM MULTIPLE DOSING. THE DETAILS OF POISON SYMPTOMS AND BLOOD CHEMISTRY EXAMINATIONS ARE REPORTED. SIX DEATHS RESULTED SHORTLY AFTER INGESTION OF PLANT MATERIAL. IN THESE CASES, 15 GM OF TRIPTERYGIUM WAS INGESTED. SUBJECTS WERE USING THE PLANT FOR TREATMENT OF ARTHRITIS. THE AUTHORS POINT OUT THAT THERE IS NO ANTIDOTE FOR THIS TYPE OF POISONING AND THAT THERE MAY BE A CUMULATIVE TOXICITY. |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |