Experiment 960226
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | YE,WH: TAO,XL: ZHANG,NZ:. (1990). MECHANISM OF TREATING RHEUMATOID ARTHRITIS WITH POLYGLYCOSIDES OF TRIPTERYGIUM WILFORDII HOOK (T-11). III. STUDY ON INHIBITORY EFFECT OF T-11 ON IN VITRO IG SECRETED BY PERIPHERAL BLOOD MONOCULEAR CELLS FROM NORMAL CONTROLS AND RHEUMATOID ARTHRITIS. 12(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE VITRO EFFECTS OF A POLYGLYCOSIDE FRACTION (T-11) OF THE TITLE PLANT WERE STUDIED ON IMMUNGLOBULIN (IG) PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS (PB-MC) FROM 17 HEALTHY PERSONS AND 8 RHEUMATOID ARTHRITIS (RA) PATIENTS. PB-MC'S, MONOCYTES AND LYMPHOCYTES WERE TREATED SEPARATELY WITH DIFFERENT DOSES OF T-II FOR DIFFERENT PERIODS OF TIME. CELLS IN DIFFERENT COMBINATIONS WERE CULTURED FOR 2 WEEKS UNDER POKEWEED MITOGEN(PWM) STIMULATION AND THE IGG AND IGM CONTENT OF CULTURE SUPERNATANTS WERE DETERMINED USING THE DOUBLE ANTIBODY SOLID-PHASE IMMUNORADIOMETRIC ASSAY. THERE WAS NO DIFFERENCE IN THE INHIBITORY EFFECT OF T-II ON INVETRO IGM AND IGG PRODUCTION BY PB-MC'S EITHER BETWEEN THE TWO TYPES OF IG OF BETWEEN HEALTHY INDIVIDUALS AND RHEUMATOID ARTHRITIS PATIENTS. T-II ACTS BOTH ON MONOCYTES + LYMPHOCYTES, BUT MORE STRONGLY ON THE LATTER. RESULTS OF THIS STUDY CORRELATE WELL WITH THOSE OF CLINICAL TRIALS, SUGGESTING THAT THE THERAPEUTIC EFFECT OF T-II IS ASSOCIATED WITH ITS IMMUNOSUPPRESSIVE ACTIVITY. |
| Dose amount | 2-50 MCG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Per unit | ML |
| Dose expression | CONC USED |
| Extract | CHROMATOGRAPHIC FRACTION |