Experiment 960653
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | ZHANG,XY: TSUCHIYA,N: DOHI,M: YAMAMOTO,K: ISHIHARA,K: OKUDAIRA,H: ITO,K: MIYAMOTO,T:. (1992). PROLONGED SURVIVAL OF MRL-LPR/LPR MICE TREATED WITH TRIPTERYGIUM WILFORDII HOOK-F.. 62(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | TOTAL "GLYCOSIDES" WERE ADMINISTERED 3 TIMES A WEEK BEGINNING AT 9 WEEKS OF AGE AT DOSE LEVELS OF 2-20 MG/KG. THE BEST RESULTS WERE FOUND AT 20 MG/KG. MICE WERE OF THE MRL-LPR/LPR STRAIN(AUTOIMMUNE). DRAMATIC PROLONGATION OF SURVIVAL AND THE REDUCTION OF URINARY PROTEIN WERE OBSERVED COMPARED WITH CONTROLS. A SLIGHT BUT SIGNIFICANT REDUCTION WAS ALSO SEEN IN THE DEGREE OF LYMPHADENOPATHY AND ARTHRITIS WITH THE HIGH DOSE TREATMENT. SURPRISINGLY, NO SIGNIFICANT DIFFERENCE WAS PRESENT IN IGM RHEUMATOID FACTOR AND IGG ANTI-DOUBLE-STRANDED DNA ANTIBODY LEVELS OR IN THE HISTOPATHOLOGY OF LUPUS NEPHRITIS. THE RESULTS INDICATE DISSOCIATION OF HISTOPATHOLOGICAL RENAL DISEASE AND THE DEGREE OF PROTEINURIA OR THE LIFE SPAN. IT IS SUGGESTED THAT THIS MAY BE POTENTIALLY USEFUL FOR DISEASES SUCH AS SYSTEMIC LUPUS ERYTHEMATOSUS OR NEPHROTIC SYNDROME. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MONKEY(CYNOMOLGUS) |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | CHROMATOGRAPHIC FRACTION |