Experiment 960677
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | KUANG,YD: ZHANG,H: QIN,WZ:. (1988). THE SUPPRESSIVE EFFECTS OF TRIPTERYGIUM WILFORDII ON INTERLEUKIN 2 (IL2) PRODUCTION AND IL2 RECEPTOR EXPRESSION.. 8(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | DNA SYNTHESIS OF MOUSE SPLEEN CELLS AND THYMOCYTES STIMULATED WITH CON A WAS INHIBITED BY TRIPTERYGIUM WILFORDII (LEIGONGTENG) IN A DOSE DEPENDENT MANNER. THE SUPPRESSION WAS STRONG IN THE FIRST HALF OF THE 72-HOUR CULTURE PERIOD. EXTRACT HAD ONLY PARTIAL SUPPRESSIVE EFFECT IN THE SECOND HALF OF THE PEROID. EXTRACT WAS FOUND TO HAVE NO CYTOTOXIC EFFECT ON THE SPLEEN CELLS. IT CAUSED COMPLETE INHIBITION ON THE EXPRESSION OF IL2 RECEPTORS OF CON A ACTIVATED SPLEEN CELLS. PARTIAL INHIBITION OF IL2 PRODUCTION WAS ALSO SEEN. THE ADDITION OF EXTRA IL2 DID NOT RESTORE THE PROLIFERATION OF SPLEEN CELLS CULTURED WITH CON A AND LEIGONGTENG. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CELL CULTURE |
| Dose expression | CONC USED |
| Extract | DECOCTION |