Experiment 960690

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismTripterygium wilfordii (CELASTRACEAE)
CitationFENG,SF: ZHENG,PS: KANG,KF: LI,YP: GONG,ZM: FU,ZM:. (1989). EFFECT OF TRIPTERYGIUM WILFORDII ON SERUM SEX HORMONE PROFILE IN FEMALE PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.. 22(1)
Amount utilized
Compound isolated
Disease31 FEMALES WITH SYSTEMIC LUPUS ERYTHREMATOSUS WERE TREATED WITH LEIGONGTENG (TRIPTERYGIUM WILFORDII) SYRUP (1.0 GM/ML. DOSAGE WAS 15 ML THREE TIMES DAILY. 21 CASES WERE TREATED FOR 6 MONTHS AND 10 CASES FOR 1-3 YEARS. SERUM ESTRADIOL AND ESTRADIOL/TESTOSTERONE RATIO, BUT NOT SERUM TESTOSTERONE, PROGESTERONE, LH, FSH AND PROLACTIN WERE HIGHER THAN NORMAL VALUES. IN THE SHORT TERM TREATMENT GROUP, ESTRADIOL AND ESTRADIOL/TESTOSTERONE, RATIO WERE DECREASED. LH AND FSH INCREASED AND TESTOSTERONE, PROGESTERONE AND PROLACTIN WERE NOT AFFECTED AFTER TREATMENT. IN THE LONG-TERM THERAPY GROUP, SERUM ESTRADIOL, TESTOSTERONE, PROLACTIN AND ESTRADIOL/TESTOSTERONE RATIO WERE CLOSE NORMAL POST-TREATMENT. BUT, LH AND FSH WERE INCREASED AND PROGESTERONE DECREASED. THE THERAPEUTIC EFFECT IS CLOSELY ASSOCIATED WITH THE DROP IN SERUM ESTRADIOL LEVEL AND ESTRADIOL/TESTOSTERONE RATIO.
Dose amount45.0 GM
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractDECOCTION
GenderFEMALE