Experiment 960695
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | HE,YX: QIAN,JQ: ZHANG,QY:. (1989). TREATMENT OF REFRACTORY NEPHROSIS WITH TRIPTERYGIUM WILFORDII.. 9(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | 15 CASES OF NEPHROSIS REFRACTORY TO STEROIDS(15 CASES) AND CYTOTOXIC DRUGS(10 CASES) WERE TREATED WITH A TABLET OF THE "GLYCOSIDES" OF TRIPTERYGIUM WILFORDII AT 30-60 MG/DAY ORALLY FOR 1.5-16.5 MONTHS. DOSAGE OF STEROIDS WAS REDUCED GRADUALLY FROM 40-80 TO 10-20 MG/DAY. TREATMENT WITH TRIPTERYGIUM WAS SUSPENDED WHEN THE WBC COUNT DROPPED TO BELOW 4 MILLION PER ML. PROTEINURIA BECAME TRACE OR DISAPPEARED IN 2 PATIENTS AND WAS REDUCED TO AT LEAST 50% IN 11 PATIENTS. BUN, CREATININE, WBC AND IGG WERE NOT SIGNIFICANTLY ALTERED. IGA AND IGM, HOWEVER, WERE SIGNIFICANTLY REDUCED. AT HIGH DOSES, THE EXTRACT CAUSED NAUSEA, ANOREXIA, SKIN PIGMENTATION, MENSTRUAL DISORDERS AND LEUKOPENIA. |
| Dose amount | 30-60 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | CHROMATOGRAPHIC FRACTION |