Experiment 960696
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | TAO,XL: SHI,YP: CHEN,XH: ZHANG,NZ:. (1988). TREATMENT OF RHEUMATOID ARTHRITIS WITH THE POLYGLYCOSIDES OF TRIPTERYGIUM WILFORDII. I. EFFECT ON THE PRODUCTION OF IGM AND IGM-RF BY PERIPHERAL BLOOD MONONUCLEAR CELLS(PBMC).. 10(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE TOTAL IGM AND IGM-RF PRODUCED BY PBMC IN VITRO WERE DETERMINED IN 56 CASES OF RHEUMATOID ARTHRITIS AND 24 NORMAL HEALTHY PERSONS. PATIENTS WITH RHEUMATOID ARTHRITIS WERE FOUND TO HAVE HIGHER IGM-RF AND IGM-RF/IGM RATIO BUT SIMILAR TOTAL IGM. IN A DOUBLE-BLIND CLINICAL TRIAL, ADMINISTRATION OF THE "POLYGLYCOSIDES" OF TRIPTERYGIUM WILFORDII FOR 3 MONTHS RESULTED IN A SIGNIFICANT INHIBITION OF PRODUCTION OF TOTAL IGM AND IGM-RF BY PBMC IN RHEUMATOID ARTHRITIS IN VITRO. BUT, THE IGM-RF/IGM RATIO WAS NOT AFFECTED. THE "POLYGLYCOSIDE" WAS ALSO FOUND TO INHIBIT THE SYNTHESIS OF TOTAL IGM AND IGM-RF INDUCED BY PHYTOLACCANINE. THE RESULTS SUGGESTED THAT THE THERAPEUTIC MECHANISM OF THE "POLYGLYCOSIDE" WAS VIA ITS IMMUNOMODULATORY ACTION ON PBMC. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | CHROMATOGRAPHIC FRACTION |