Experiment 960705
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | LOU,D: XU,WY:. (1990). IMMUNOREGULATORY EFFECTS OF MONOMER T4 FROM TRIPTERYGIUM WILFORDII. I. IMMUNOREGULATORY EFFECTS OF T4 ON NK ACTIVITY OF MOUSE SPLENOCYTES.. 12(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | EFFECTS OF MONOMER T4(TRIPCHLOROLIDE) ON NK ACTIVITY OF MOUSE SPLENOCYTES WERE DETERMINED BOTH IN VITRO AND IN VIVO BY MEANS OF A CLASSICAL I-UDR RELEASE ASSAY. THE RESULTS SHOWED THAT THE MONOMER T4 EXHIBITED DOSE-DEPENDENT DOUBLE-REGULATORY EFFECTS. AT LOW DOSAGE IT ENHANCED THE PERCENTAGE OF NK CYTOTOXICITY, AT HIGH DOSAGE IT SHOWED DOSE DEPENDENT INHIBITION. THE DOUBLE-REGULATORY EFFECTS OF MONOMER T4 MIGHT BE IMPORTANT FOR THE EVALUATION OF THERAPEUTIC EFFECTS OF TRIPTERYGIUM WILFORDII IN FUTURE CLINICAL PRACTICE. |
| Dose amount | LOW |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Dose expression | DOSE |