Experiment 963013
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | QIAN,SZ:. (1987). TRIPTERYGIUM WILFORDII, A NEW LEAD IN MALE FERTERILITY REGULATION.. 36() |
| Amount utilized | |
| Compound isolated | |
| Disease | A REVIEW WITH 26 REFERENCES. THE MAIN SIDE EFFECTS WITH A DECOCTION OF THE ROOTWOOD OR THE TOTAL GLYCOSIDES (GTW) ARE GASTOINTESTINAL DISTURBANCES, INCLUDING NAUSEA, VOMITING, ANOREXIA, EPIGASTRIC BURNING SENSATION, XEROSTOMIA, DIARRHEA, CONSTIPATION. MOST OF THESE EFFECTS SUBSIDE IN THE COURSE OF TREATMENT AND DISCONTINUATION OF DRUG THERAPY IS USUALLY NOT NECESSARY. LEUCOPENIA AND THROMBOCYTOPENIA MAY BE FOUND IN A FEW PATIENTS BUT THE CELL COUNTS RECOVER AFTER WITHDRAWLA OF THE DRUG. OTHER SIDE EFFECTS INCLUDE MENSTRUAL DISTURBANCES, OLIGOSPERMIA, AZOOSPERMIA AND A DECREASE IN THE SIZE OF THE TESTIS. THE SIDE EFFECTS OF GTW ARE MUCH LESS THAN THOSE OF THE CRUDE EXTRACT AND THE DRUG HAS BEEN USED IN OUTPATIENTS. |
| Dose amount | 1.5 MG |
| Number | 5 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | CHROMATOGRAPHIC FRACTION |
| Gender | GIVEN TO BOTH SEXES |