Experiment 964815
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | ZEMER,D: LIVNEH,A: DANON,YL: PRAS,M: SOHAR,E:. (1991). LONG-TERM COLCHICINE TREATMENT IN CHILDREN WITH FAMILIAL MEDITERRANEAN FEVER.. 34(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | THREE HUNDRED AND FIFTY CHILDREN SUFFERING FROM FAMILIAL MEDITERRANEAN FEVER WERE BEGUN ON DOSES OF GIVEN COMPOUND OF 1-2 MG/DAY BEFORE THE AGE OF 16. THESE HAVE CONTINUED FOR 6-13 YEARS WITH 64% SHOWING COMPLETE REMISSION AND 31% PARTIAL. PROTRACTED ATTACKS OF ARTHRITIS ARE RARE AND AMYLOIDOSIS HAS DEVELOPED IN NONE OF THE PATIENTS. SIDE EFFECTS OF DIARRHEA AND NAUSEA WERE TREATABLE. NO ABNORMALITY IN GROWTH, DEVELOPMENT OR FERTILITY HAVE BEEN NOTED. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |