Experiment 965759
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | GALITZKY,J: RIVIERE,D: TRAN,MA: MONTASTRUC,JL: BERLAN,M:. (1990). PHARMACODYNAMIC EFFECTS OF CHRONIC YOHIMBINE TREATMENT IN HEALTHY VOLUNTEERS.. 39(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECTS OF 14 DAYS TREATMENT WITH YOHIMBINE ON CARDIOVASCULAR (BLOOD PRESSURE AND HEART RATE) PARAMETERS, PLASMA CATECHOLAMINES, INSULIN, NON-ESTERIFIED FATTY ACIDS (NEFA) AND THE NUMBER OF ALPHA-2-ADRENOCEPTORS ON PLATELETS ARE DESCRIBED. TREATMENT INCREASE PLASMA NORADRENALIN BUT NOT AFRENALIN AND DID NOT CHANGE THE OTHER CARDIOVASCULAR, METABOLIC OR ROUTINE BLOOD PARAMETERS. IT CAUSED A DECREASE IN THE VELOCITY OF ADRENALIN-INDUCED PLATELET AGGREGATION. YOHIMBINE BINDING TO PLATELETS REMAINED UNCHANGED. ACUTE ADMINISTRATION OF YOHIMBINE BEFORE THE EXPERIMENT LED TO A SIGNIFICANT INCREASE IN PLASMA NORADRENALIN AND NEFA LEVELS. AFTER THE 15 DAY TREATMENT, ACUTE ADMINISTRATION OF THE SAME DOSE OF YOHIMBINE HAD LESS EFFECT ON PLASMA NEFA AND THERE WAS NO CHANGE IN PLASMA NORADRENALIN. THE ACUTE LIPID-MOBILIZING EFFECT OF YOHIMBINE IN HEALTH VOLUNTEERS PERSISTED AFTER THE 14 DAYS OF TREATMENT WITH NO CHANGE IN OTHER PARAMETERS. THE PROLONGED ALPHA-2-ADRENOCEPTOR BLOCKAGE WITH YOHIMBINE DID NOT INDUCE ANY CHANGE IN PLATELET ALPHA-2-ADRENOCEPTORS. |
| Dose amount | 0.2 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |