Experiment 969278

Worktypes

PHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

BRYOSTATIN 1

Details

PropertyValue
Pharmacology
RADIOPROTECTIVE EFFECT
OrganismEmpty organism
CitationGRANT,S: PETTIT,GR: MC CRADY,C:. (1992). EFFECT OF BRYOSTATIN 1 ON THE IN VITRO RADIOPROTECTIVE CAPACITY OF RECOMBINANT GRANULOCYTE-MARCOPHAGE COLONY-STIMULATING FACTOR (RGM-CSF) TOWARD COMMITTED HUMAN MYELOID PROGENITOR CELLS (CFU-GM).. 20(1)
Amount utilized
Compound isolated
DiseaseCELLS EXPOSED TO CMPD AND RECOMBINANT GRANLUOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (RGM-CSF) HAD A 18-30% SURVIVAL FOLLOWING 4-5 GY IRRADIATION VS. NONE IN CELLS TREATED ONLY WITH RGM-CSF. EFFECT WAS LESSENED IF INCUBATION WITH CMPDS OCCURRED AFTER IRRADIATION.
Dose amount1.25 NANOMOLS
Number1
Qualitative resultACTIVE
AnimalCELL CULTURE
Dose expressionCONC USED