Experiment 972722
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | SOONS,PA: VOGELS,BAPM: ROOSEMALEN,MCM: SCHOEMAKER,HC: UCHIDA,E: EDGAR,B: LUNDAHL,J: COHEN,AF: BREIMER,DD:. (1991). PHARMACOKINETICS AND DRUG DISPOSITION. GRAPEFRUIT JUICE AND CIMETIDINE INHIBIT STEREOSELECTIVE METABOLISM OF NITRENDIPINE IN HUMANS.. 50(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | PLACEBO-CONTROLLED CROSSOVER STUDY OF NINE HEALTY MEN TO ASSESS EFFECT OF EXTRACT GIVEN AT -15, -10, -0.25, 5 AND 10 HRS ON PHARMACOKINETICS OF NITRENDIPINE. AUC WERE INCREASED BUT NOT STEROSPECIFICALLY. THERE WAS NO EFFECT ON BLOOD PRESSURE. |
| Dose amount | 150.0 ML |
| Number | 3 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Extract | JUICE |