Experiment 972749
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | BRUCHERT,E: HEINRICH,SE: RUF-KOHLER,P:. (1991). EFFICACY OF LI1370 IN ELDERLY PATIENTS WITH CEREBRAL INSUFFICIENCY.. 133() |
| Amount utilized | |
| Compound isolated | |
| Disease | IN 33 GENERAL PRACTITIONERS' PRACTICES A PLACEBO-CONTROLLED DOUBLE-BLIND STUDY CONCERNING THE EFFICACY OF A GINKGO BILOBA SPECIAL EXTRACT IN ELDERLY PATIENTS WITH CEREBRAL INSUFFICIENCY WAS CARRIED OUT WITH 303 OUTPATIENTS. THE DOSAGE WAS 3 X 1 COATED TABLETS OF 50 MG GINKGO BILOBA SPECIAL EXTRACT DAILY FOR 12 WEEKS. CONTROLS TOOK PLACE AFTER THE 6TH AND 12TH THERAPY WEEK. SIGNS OF CEREBRAL INSUFFICIENCY AS WELL AS THE FIGURE CONNECTION TEST AND THAT AT THE END OF THE THERAPY THE DOCTOR'S AND PATIENTS'S JUDGEMENT ON THE EFFICACY OF THE EFFICACY OF THE PREPARATION WERE TAKEN INTO ACCOUNT. 209 PROTOCOLS WERE AVAILABLE FOR THE STATISTICAL EVALUATION. STATISTICALLY SIGNIFICANT IMPROVEMENTS WERE DEMONSTRATED AFTER 6 WEEKS OF THERAPY ON 3 OUT OF 11 TYPICAL SYMPTOMS AND AFTER 12 WEEKS OF THERAPY ON 8 OUT OF 11. IN THE ACTIVE GROUP THE TIME PERIOD FOR THE FIGURE CONNECTION TEST WAS IMPROVED BY 25%, IN THE PLACEBO GROUP ONLY 14% (P <0,01 IN COMPARISON BETWEEN THE GROUPS). BOTH THE DOCTOR'S AND THE PATIENT'S JUDGEMENT CONCERNING THE EFFICACY SHOW HIGHLY SIGNIFICANT DIFFERENCES BETWEENS THE TWO GROUPS. THE INCIDENCE OF SIDE EFFECTS WAS HALF AS HIGH IN THE VERUM GROUP COMPARED TO THE PLACEBO GROUP. |
| Dose amount | 150.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(30%)EXT |