Experiment 973083
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | TIEGS,G: FREUDENBERG,MA: GALANOS,C: WENDEL,A:. (1992). COLCHICINE PREVENTS TUMOR NECROSIS FACTOR-INDUCED TOXICITY IN VIVO.. 60(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | COMPOUND, ADMINISTERED AT 19 AND 4 HRS BEFORE CHALLENGE WITH TUMOR NECROSIS FACTOR ALPHA, PREVENTED HEPATITIS INDUCED BY TNF-ALPHA IN GALACTOSAMINE-SENSITIZED C3H/HEJ ANIMALS. ONLY PRETREATMENT OF ANIMALS AS OPPOSED TO PRETREATMENT OF LPS-STIMULATED MACROPHAGES, PREVENTED HEPATITIS PRODUCED BY INJECTION OF SUCH MACROPHAGES. |
| Dose amount | 0.5 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | DOSE |