Experiment 974143

Details

PropertyValue
Pharmacology
OrganismEmpty organism
CitationAKAO,T: AKAO,T: AOYAMA,M: KOBASHI,K:. (1991). METABOLISM OF GLYCYRRHETIC ACID BY RAT LIVER MICROSOMES-III. MALE-SPECIFIC GLYCYRRHETINATE DEHYDROGENASE.. 42(1)
Amount utilized
Compound isolated
DiseaseTHIS ENZYME WAS FOUND IN MALES BUT NOT FEMALES.. ESTRADIOL INHIBITED ITS EXPRESSION IN MALES WHILE TESTOSTERONE WAS NECESSARY FOR ITS EXPRESSION IN OVARIECTOMIZED FEMALES. HYPOPHYSECTOMIZED ANIMALS OF EITHER SEX SHOWED 20-40% ACTIVITY OF NORMAL MALES, AND ESTRADIOL NO LONGER HAD A SUPPRESSIVE EFFECT.
Dose amount0.1 MILLIMOLS
Number1
Qualitative resultACTIVE
AnimalRAT
Dose expressionCONC USED