Experiment 993144

Details

PropertyValue
Pharmacology
Administration routeIV
OrganismEmpty organism
CitationJI,XJ: LIU,JS: LIU,ZM:. (1979). METABOLISM OF HARRINGTONINE.. 14(4)
Amount utilized
Compound isolated
Disease15 MINUTES AFTER INJECTION THE HIGHEST LEVEL OF RADIOACTIVITY WAS IN THE KIDNEYS,WITH APPRECIABLE AMOUNTS IN THE LIVER,BONE MARROW,LUNG,HEART,GI TRACT,SPLEEN AND MUSCLE.LEVELS IN TESTES,WHOLE BLOOD AND BRAIN WERE LOW. TWO HOURS AFTER INJECTION,DRUG CONCENTRATION IN VARIOUS TISSUES DECREASED RAPIDLY,BUT THAT OF THE BONE MARROW DECREASED MORE SLOWLY. 24 HOURS AFTER ADMINISTRATION,ONLY VERY LOW LEVELS OF ACTIVITY WERE FOUND IN ALL TISSUES. TOTAL URINARY EXCRETION WAS 30.2% AFTER 24 HOURS:14.5% EXCRETED IN FECES UNCHANGED:24.5% IN BILE.
Number1
Qualitative resultACTIVE
AnimalRAT
Dose expressionDOSE