Experiment 995460
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Symphytum uplandicum (BORAGINACEAE) |
| Citation | CULVENOR,CCJ: CLARKE,M: EDGAR,JA: FRAHN,JL: JAGO,MV: PETERSON,JE: SMITH,LW:. (1980). STRUCTURE AND TOXICITY OF THE ALKALOIDS OF RUSSIAN COMFREY (SYMPHYTUM X UPLANDICUM NYMAN), A MEDICINAL HERB AND ITEM OF HUMAN DIET.. 36() |
| Amount utilized | |
| Compound isolated | |
| Disease | DOSING 3 TIMES WEEKLY TO HOODED RATS,STARTING AT 14 DAYS OF AGE.ASSAY PERFORMED AFTER 3 WEEKS OF DOSING DEATH WITHIN 3-4 WEEKS WITH SEVERELY IMPAIRED LIVER FUNCTION.MITOTIC INDEX IN PARENCHYMAL CELLS WAS GREATLY REDUCED TOTAL PLASMA PROTEIN AND ALBUMIN/GLOBULIN RATIO WERE REDUCED 40% OR MORE |
| Dose amount | 71.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | TOTAL ALKALOIDS |
| Gender | GIVEN TO BOTH SEXES |