Citation 125523

BAI,R: CICHACZ,ZA: HERALD,CL: PETTIT,GR: HAMEL,E:. (1993). SPONGISTATIN 1, A HIGHLY CYTOTOXIC, SPONGE-DERIVED, MARINE NATURAL PRODUCT THAT INHIBITS MITOSIS, MICROTUBULE ASSEMBLY, AND THE BINDING OF VINBLASTINE TO TUBULIN.. 44(4)

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Title	SPONGISTATIN 1, A HIGHLY CYTOTOXIC, SPONGE-DERIVED, MARINE NATURAL PRODUCT THAT INHIBITS MITOSIS, MICROTUBULE ASSEMBLY, AND THE BINDING OF VINBLASTINE TO TUBULIN.
Authors	BAI,R: CICHACZ,ZA: HERALD,CL: PETTIT,GR: HAMEL,E:
Year	1993
Volume	44
Issue	4

Summary

Year: 1993

Journal: Unknown

Organisms and Their Experiments (5)

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	SPONGIASTATIN 1	STRONG ACTIVITY
2	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 1	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 1	ACTIVE
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	SPONGIASTATIN 1	ACTIVE
5	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 1	ACTIVE
6	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 1	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	HALICHONDRIN B	ACTIVE
2	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	HALICHONDRIN B	ACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HALICHONDRIN B	ACTIVE
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	HALICHONDRIN B	ACTIVE
5	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	HALICHONDRIN B	ACTIVE
6	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	HALICHONDRIN B	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	DOLASTATIN 10	ACTIVE
2	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 10	INACTIVE
3	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 10	ACTIVE
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	DOLASTATIN 10	ACTIVE
5	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 10	ACTIVE
6	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 10	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	ANTIMITOTIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	VINCALEUKOBLASTINE	ACTIVE
2	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	VINCALEUKOBLASTINE	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE	ACTIVE

Citation 125523

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Summary

Organisms and Their Experiments (5)

Unknown organism

Unknown organism

Unknown organism

Unknown organism

Unknown organism

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