Citation 128288

BAI,R: TAYLOR,GF: CICHACZ,ZA: HERALD,CL: KEPLER,JA: PETTIT,GR: HAMEL,E:. (1995). THE SPONGIASTATINS, POTENTLY CYTOTOXIC INHIBITORS OF TUBULIN POLYMERIZATION, BIND IN A DISTINCT REGION OF THE VINCA DOMAIN.. 34(30)

Citation Details

Title	THE SPONGIASTATINS, POTENTLY CYTOTOXIC INHIBITORS OF TUBULIN POLYMERIZATION, BIND IN A DISTINCT REGION OF THE VINCA DOMAIN.
Authors	BAI,R: TAYLOR,GF: CICHACZ,ZA: HERALD,CL: KEPLER,JA: PETTIT,GR: HAMEL,E:
Year	1995
Volume	34
Issue	30

Summary

Year: 1995

Journal: Unknown

Organisms and Their Experiments (3)

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	SPONGIASTATIN 1	STRONG ACTIVITY
2	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 1	ACTIVE
3	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 1	ACTIVE
4	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 1	ACTIVE
5	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 1	ACTIVE
6	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	SPONGIASTATIN 2	STRONG ACTIVITY
7	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 2	ACTIVE
8	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 2	ACTIVE
9	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 2	ACTIVE
10	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 2	WEAK ACTIVITY
11	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	SPONGIASTATIN 3	STRONG ACTIVITY
12	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 3	ACTIVE
13	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 3	WEAK ACTIVITY
14	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 3	WEAK ACTIVITY
15	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 3	WEAK ACTIVITY
16	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	SPONGIASTATIN 4	STRONG ACTIVITY
17	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 4	ACTIVE
18	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 4	ACTIVE
19	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 4	ACTIVE
20	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 4	ACTIVE
21	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	SPONGIASTATIN 5	STRONG ACTIVITY
22	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 5	ACTIVE
23	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 5	ACTIVE
24	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 5	ACTIVE
25	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 5	ACTIVE
26	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	SPONGIASTATIN 6	STRONG ACTIVITY
27	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 6	ACTIVE
28	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 6	ACTIVE
29	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 6	EQUIVOCAL
30	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 6	EQUIVOCAL
31	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	SPONGIASTATIN 7	STRONG ACTIVITY
32	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 7	ACTIVE
33	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 7	ACTIVE
34	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 7	ACTIVE
35	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 7	WEAK ACTIVITY
36	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	SPONGIASTATIN 8	STRONG ACTIVITY
37	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 8	ACTIVE
38	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 8	ACTIVE
39	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 8	EQUIVOCAL
40	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 8	EQUIVOCAL
41	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	SPONGIASTATIN 9	STRONG ACTIVITY
42	TUBULIN POLYMERIZATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 9	ACTIVE
43	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 9	ACTIVE
44	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 9	ACTIVE
45	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	SPONGIASTATIN 9	ACTIVE
46	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	DOLASTATIN 10	ACTIVE
47	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	HALICHONDRIN B	ACTIVE

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	VINCALEUKOBLASTINE	EQUIVOCAL
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	LEUROCRISTINE	WEAK ACTIVITY
3	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	MAYTANSINE	WEAK ACTIVITY

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	PHOMOPSIN A	ACTIVE
2	TUBULIN BINDING INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	RHIZOXIN	EQUIVOCAL

Citation 128288

Citation Details

Summary

Organisms and Their Experiments (3)

Unknown organism

Unknown organism

Unknown organism

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