Citation 75463

NISHIDA,H: SAKAKIBARA,T: AOKI,F: SAITO,T: ICHIKAWA,K: INAGAKI,T: KOJIMA,Y: YAMAUCHI,Y: HUANG,LH: GUADLIANA,MA: KANEKO,T: KOJIMA,N:. (1995). GENERATION OF NOVEL RAPAMYCIN STRUCTURES BY MICROBIAL MANIPULATIONS.. 48(7)

Citation Details

Title	GENERATION OF NOVEL RAPAMYCIN STRUCTURES BY MICROBIAL MANIPULATIONS.
Authors	NISHIDA,H: SAKAKIBARA,T: AOKI,F: SAITO,T: ICHIKAWA,K: INAGAKI,T: KOJIMA,Y: YAMAUCHI,Y: HUANG,LH: GUADLIANA,MA: KANEKO,T: KOJIMA,N:
Year	1995
Volume	48
Issue	7

Summary

Year: 1995

Journal: Unknown

Organisms and Their Experiments (2)

Unknown organism

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,27-DEMETHOXY:	WEAK ACTIVITY
2	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	CYCLOSPORIN ARAPAMYCIN,27-DEMETHOXY:	ACTIVE
3	CELL PROLIFERATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CYCLOSPORIN A	ACTIVE
4	CELL PROLIFERATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	CYCLOSPORIN A	WEAK ACTIVITY
5	DELAYED TYPE CUTANEOUS HYPERSENSITIVITY INHIBITION	PHARMACOLOGY OF COMPOUND - IN VIVO	CYCLOSPORIN A	ACTIVE

Actinoplanes species (ACTINOPLANACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	RAPAMYCIN,16-27-BISDEMETHYL:	None
2	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,16-27-BISDEMETHYL:	ACTIVE
3	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	RAPAMYCIN,16-O-DEMETHYL:	None
4	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,16-O-DEMETHYL:	ACTIVE
5	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	RAPAMYCIN,27-DEMETHOXY-39-O-DEMETHYL:	None
6	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,27-DEMETHOXY-39-O-DEMETHYL:	WEAK ACTIVITY
7	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	RAPAMYCIN,27-O-DEMETHYL:	None
8	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,27-O-DEMETHYL:	ACTIVE
9	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	RAPAMYCIN,PROLYL:	None
10	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,PROLYL:	ACTIVE
11	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	RAPAMYCIN,PROLYL: 27-O-DEMETHYL:	None
12	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,PROLYL: 27-O-DEMETHYL:	ACTIVE
13	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	RAPAMYCIN,39-O-DEMETHYL:	None
14	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,39-O-DEMETHYL:	ACTIVE
15	CELL PROLIFERATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	RAPAMYCIN,39-O-DEMETHYL:	ACTIVE
16	CELL PROLIFERATION INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	RAPAMYCIN,39-O-DEMETHYL:	ACTIVE
17	DELAYED TYPE CUTANEOUS HYPERSENSITIVITY INHIBITION	PHARMACOLOGY OF COMPOUND - IN VIVO	RAPAMYCIN,39-O-DEMETHYL:	ACTIVE
18	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	RAPAMYCIN,9-DEOXO:	None
19	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,9-DEOXO:	WEAK ACTIVITY
20	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	RAPAMYCIN,9-DEOXO-27-DEMETHOXY:	None
21	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,9-DEOXO-27-DEMETHOXY:	WEAK ACTIVITY
22	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	RAPAMYCIN,28-DEHYDROXY:	None
23	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,28-DEHYDROXY:	WEAK ACTIVITY
24	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	RAPAMYCIN,9-DEOXO-27-DEMETHOXY-39-O-DEMETHYL:	None
25	IMMUNOSUPPRESSANT ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE	RAPAMYCIN,9-DEOXO-27-DEMETHOXY-39-O-DEMETHYL:	WEAK ACTIVITY