Citation 75546

CONCEPCION,GP: FODERARO,TA: ELDREDGE,GS: LOBKOVSKY,E: CLARDY,J: BARROWS,LR: IRELAND,CM:. (1995). TOPOISOMERASE II-MEDIATED DNA CLEAVAGE BY ADOCIA- AND XESTOQUINONES FROM THE PHILIPPINE SPONGE XESTOSPONGIA SP.. 38(22)

Citation Details

Title	TOPOISOMERASE II-MEDIATED DNA CLEAVAGE BY ADOCIA- AND XESTOQUINONES FROM THE PHILIPPINE SPONGE XESTOSPONGIA SP.
Authors	CONCEPCION,GP: FODERARO,TA: ELDREDGE,GS: LOBKOVSKY,E: CLARDY,J: BARROWS,LR: IRELAND,CM:
Year	1995
Volume	38
Issue	22

Summary

Year: 1995

Journal: Unknown

Organisms and Their Experiments (1)

Xestospongia species (PETROSIIDAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	UV SPECTRUM GIVEN FORISOLATION AND IDENTIFICATION OFPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FOR	ADOCIAQUINONE A	None
2	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ADOCIAQUINONE A	WEAK ACTIVITY
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ADOCIAQUINONE A	WEAK ACTIVITY
4	TOPOISOMERASE II INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	ADOCIAQUINONE A	ACTIVE
5	Not specified	UV SPECTRUM GIVEN FORISOLATION AND IDENTIFICATION OFPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FOR	ADOCIAQUINONE B	None
6	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ADOCIAQUINONE B	WEAK ACTIVITY
7	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ADOCIAQUINONE B	WEAK ACTIVITY
8	TOPOISOMERASE II INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	ADOCIAQUINONE B	ACTIVE
9	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	ADOCIAQUINONE A,SECO:	None
10	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ADOCIAQUINONE A,SECO:	INACTIVE
11	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ADOCIAQUINONE A,SECO:	INACTIVE
12	TOPOISOMERASE II INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	ADOCIAQUINONE A,SECO:	ACTIVE
13	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	ADOCIAQUINONE B,SECO:	None
14	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ADOCIAQUINONE B,SECO:	INACTIVE
15	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	ADOCIAQUINONE B,SECO:	INACTIVE
16	TOPOISOMERASE II INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	ADOCIAQUINONE B,SECO:	ACTIVE
17	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	XESTOQUINONE,14-METHOXY:	None
18	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	XESTOQUINONE,14-METHOXY:	WEAK ACTIVITY
19	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	XESTOQUINONE,14-METHOXY:	ACTIVE
20	TOPOISOMERASE II INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	XESTOQUINONE,14-METHOXY:	ACTIVE
21	Not specified	MASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	XESTOQUINONE,15-METHOXY:	None
22	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	XESTOQUINONE,15-METHOXY:	WEAK ACTIVITY
23	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	XESTOQUINONE,15-METHOXY:	ACTIVE
24	TOPOISOMERASE II INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	XESTOQUINONE,15-METHOXY:	ACTIVE
25	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDX-RAY CHRYSTALLOGRAPHIC STUDIESINFRARED SPECTRUM REPORTED FORISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	XESTOQUINONE,15-CHLORO-14-HYDROXY:	None
26	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	XESTOQUINONE,15-CHLORO-14-HYDROXY:	WEAK ACTIVITY
27	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	XESTOQUINONE,15-CHLORO-14-HYDROXY:	WEAK ACTIVITY
28	TOPOISOMERASE II INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	XESTOQUINONE,15-CHLORO-14-HYDROXY:	ACTIVE
29	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	XESTOQUINONE,14-CHLORO-15-HYDROXY:	None
30	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	XESTOQUINONE,14-CHLORO-15-HYDROXY:	WEAK ACTIVITY
31	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITROANTICANCER AND/OR CYTOTOXICITY MARKER CODE	XESTOQUINONE,14-CHLORO-15-HYDROXY:	WEAK ACTIVITY
32	TOPOISOMERASE II INHIBITION	PHARMACOLOGY OF COMPOUND - IN VITRO	XESTOQUINONE,14-CHLORO-15-HYDROXY:	ACTIVE

Citation 75546

Citation Details

Summary

Organisms and Their Experiments (1)

Xestospongia species (PETROSIIDAE)

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