Citation 85123

ITO,A: CHAI,HB: SHIN,YG: GARCIA,R: MEJIA,M: GAO,Q: FAIRCHILD,CR: LANE,KE: MENENDEZ,AT: FARNSWORTH,NR: CORDELL,GA: PEZZUTO,JM: KINGHORN,AD:. (2000). CYTOTOXIC CONSTITUENTS OF THE ROOTS OF EXOSTEMA ACUMINATUM.. 56(35)

Citation Details

Title	CYTOTOXIC CONSTITUENTS OF THE ROOTS OF EXOSTEMA ACUMINATUM.
Authors	ITO,A: CHAI,HB: SHIN,YG: GARCIA,R: MEJIA,M: GAO,Q: FAIRCHILD,CR: LANE,KE: MENENDEZ,AT: FARNSWORTH,NR: CORDELL,GA: PEZZUTO,JM: KINGHORN,AD:
Year	2000
Volume	56
Issue	35

Summary

Year: 2000

Journal: Unknown

Organisms and Their Experiments (1)

Exostema acuminatum (RUBIACEAE)

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	CYTOTOXIC ACTIVITY	VOUCHER SPECIMEN REPORTED FORPHARMACOLOGY OF EXTRACT - IN VITRO	None	ACTIVE
2	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDX-RAY CHRYSTALLOGRAPHIC STUDIESINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	KAUR-4-EN-ONE,19-NOR: 16(R)-17-DIHYDROXY: ENT:	None
3	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-ONE,19-NOR: 16(R)-17-DIHYDROXY: ENT:	INACTIVE
4	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-ONE,19-NOR: 16(R)-17-DIHYDROXY: ENT:KAUR-4-EN-3-ONE,19-NOR: 16(S)-17-DIHYDROXY: ENT:COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:	INACTIVE
5	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-ONE,19-NOR: 16(R)-17-DIHYDROXY: ENT:	WEAK ACTIVITY
6	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-ONE,19-NOR: 16(R)-17-DIHYDROXY: ENT:	INACTIVE
7	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-ONE,19-NOR: 16(R)-17-DIHYDROXY: ENT:	INACTIVE
8	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-ONE,19-NOR: 16(R)-17-DIHYDROXY: ENT:	INACTIVE
9	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-ONE,19-NOR: 16(R)-17-DIHYDROXY: ENT:COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:COUMARIN,4-PHENYL: 5-HYDROXY-4'-7-DIMETHOXY:EXOSTEMIN I	INACTIVE
10	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-ONE,19-NOR: 16(R)-17-DIHYDROXY: ENT:COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:COUMARIN,4-PHENYL: 5-HYDROXY-4'-7-DIMETHOXY:EXOSTEMIN I	INACTIVE
11	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-ONE,19-NOR: 16(R)-17-DIHYDROXY: ENT:	INACTIVE
12	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-ONE,19-NOR: 16(R)-17-DIHYDROXY: ENT:COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:	INACTIVE
13	Not specified	UV SPECTRUM GIVEN FORMASS-SPECTRAL FRAGMENTATION REPORTEDPMR SPECTRUM REPORTEDCMR SPECTRUM REPORTEDINFRARED SPECTRUM REPORTED FORQUANTITATIVE DATAISOLATION OF A COMPOUND WITH NOVEL STRUCTURE	KAUR-4-EN-3-ONE,19-NOR: 16(S)-17-DIHYDROXY: ENT:	None
14	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-3-ONE,19-NOR: 16(S)-17-DIHYDROXY: ENT:	WEAK ACTIVITY
15	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-3-ONE,19-NOR: 16(S)-17-DIHYDROXY: ENT:	INACTIVE
16	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-3-ONE,19-NOR: 16(S)-17-DIHYDROXY: ENT:	WEAK ACTIVITY
17	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-3-ONE,19-NOR: 16(S)-17-DIHYDROXY: ENT:	WEAK ACTIVITY
18	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-3-ONE,19-NOR: 16(S)-17-DIHYDROXY: ENT:	WEAK ACTIVITY
19	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-3-ONE,19-NOR: 16(S)-17-DIHYDROXY: ENT:	ACTIVE
20	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-3-ONE,19-NOR: 16(S)-17-DIHYDROXY: ENT:	WEAK ACTIVITY
21	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-3-ONE,19-NOR: 16(S)-17-DIHYDROXY: ENT:	WEAK ACTIVITY
22	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	KAUR-4-EN-3-ONE,19-NOR: 16(S)-17-DIHYDROXY: ENT:	WEAK ACTIVITY
23	Not specified	ISOLATION AND IDENTIFICATION OFCMR SPECTRUM REPORTEDQUANTITATIVE DATA	COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:	None
24	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:	WEAK ACTIVITY
25	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:	WEAK ACTIVITY
26	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:	ACTIVE
27	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:	WEAK ACTIVITY
28	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:	WEAK ACTIVITY
29	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:	WEAK ACTIVITY
30	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	COUMARIN,4-PHENYL: 4'-5-7-TRIMETHOXY:	ACTIVE
31	Not specified	ISOLATION AND IDENTIFICATION OFCMR SPECTRUM REPORTEDQUANTITATIVE DATA	COUMARIN,4-PHENYL: 5-HYDROXY-4'-7-DIMETHOXY:	None
32	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 5-HYDROXY-4'-7-DIMETHOXY:	WEAK ACTIVITY
33	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 5-HYDROXY-4'-7-DIMETHOXY:	WEAK ACTIVITY
34	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 5-HYDROXY-4'-7-DIMETHOXY:	ACTIVE
35	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 5-HYDROXY-4'-7-DIMETHOXY:	ACTIVE
36	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 5-HYDROXY-4'-7-DIMETHOXY:	ACTIVE
37	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 5-HYDROXY-4'-7-DIMETHOXY:	ACTIVE
38	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 5-HYDROXY-4'-7-DIMETHOXY:	ACTIVE
39	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 5-HYDROXY-4'-7-DIMETHOXY:	WEAK ACTIVITY
40	Not specified	ISOLATION AND IDENTIFICATION OFCMR SPECTRUM REPORTEDQUANTITATIVE DATA	COUMARIN,4-PHENYL: 3'-HYDROXY-4'-5-7-TRIMETHOXY:	None
41	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-HYDROXY-4'-5-7-TRIMETHOXY:	ACTIVE
42	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-HYDROXY-4'-5-7-TRIMETHOXY:	STRONG ACTIVITY
43	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-HYDROXY-4'-5-7-TRIMETHOXY:	STRONG ACTIVITY
44	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-HYDROXY-4'-5-7-TRIMETHOXY:	STRONG ACTIVITY
45	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-HYDROXY-4'-5-7-TRIMETHOXY:	STRONG ACTIVITY
46	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-HYDROXY-4'-5-7-TRIMETHOXY:	STRONG ACTIVITY
47	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-HYDROXY-4'-5-7-TRIMETHOXY:	STRONG ACTIVITY
48	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-HYDROXY-4'-5-7-TRIMETHOXY:	STRONG ACTIVITY
49	Not specified	ISOLATION AND IDENTIFICATION OFCMR SPECTRUM REPORTEDQUANTITATIVE DATA	EXOSTEMIN I	None
50	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	EXOSTEMIN I	STRONG ACTIVITY
51	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	EXOSTEMIN I	ACTIVE
52	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	EXOSTEMIN I	STRONG ACTIVITY
53	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	EXOSTEMIN I	STRONG ACTIVITY
54	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	EXOSTEMIN I	STRONG ACTIVITY
55	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	EXOSTEMIN I	STRONG ACTIVITY
56	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	EXOSTEMIN I	STRONG ACTIVITY
57	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	EXOSTEMIN I	STRONG ACTIVITY
58	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVO	EXOSTEMIN I	ACTIVE
59	Not specified	ISOLATION AND IDENTIFICATION OFQUANTITATIVE DATA	COUMARIN,4-PHENYL: 3'-8-DIHYDROXY-4'-5-7-TRIMETHOXY:	None
60	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-8-DIHYDROXY-4'-5-7-TRIMETHOXY:	ACTIVE
61	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-8-DIHYDROXY-4'-5-7-TRIMETHOXY:	ACTIVE
62	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-8-DIHYDROXY-4'-5-7-TRIMETHOXY:	ACTIVE
63	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-8-DIHYDROXY-4'-5-7-TRIMETHOXY:	STRONG ACTIVITY
64	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-8-DIHYDROXY-4'-5-7-TRIMETHOXY:	ACTIVE
65	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-8-DIHYDROXY-4'-5-7-TRIMETHOXY:	ACTIVE
66	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-8-DIHYDROXY-4'-5-7-TRIMETHOXY:	STRONG ACTIVITY
67	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-8-DIHYDROXY-4'-5-7-TRIMETHOXY:	STRONG ACTIVITY
68	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-8-DIHYDROXY-4'-5-7-TRIMETHOXY:	STRONG ACTIVITY
69	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-8-DIHYDROXY-4'-5-7-TRIMETHOXY:	ACTIVE
70	Not specified	ISOLATION AND IDENTIFICATION OFCMR SPECTRUM REPORTEDQUANTITATIVE DATA	COUMARIN,4-PHENYL: 3'-5-DIHYDROXY-4'-7-DIMETHOXY:	None
71	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-5-DIHYDROXY-4'-7-DIMETHOXY:	ACTIVE
72	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-5-DIHYDROXY-4'-7-DIMETHOXY:	WEAK ACTIVITY
73	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-5-DIHYDROXY-4'-7-DIMETHOXY:	ACTIVE
74	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-5-DIHYDROXY-4'-7-DIMETHOXY:	STRONG ACTIVITY
75	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-5-DIHYDROXY-4'-7-DIMETHOXY:	ACTIVE
76	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-5-DIHYDROXY-4'-7-DIMETHOXY:	ACTIVE
77	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-5-DIHYDROXY-4'-7-DIMETHOXY:	STRONG ACTIVITY
78	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-5-DIHYDROXY-4'-7-DIMETHOXY:	STRONG ACTIVITY
79	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-5-DIHYDROXY-4'-7-DIMETHOXY:	ACTIVE
80	CYTOTOXIC ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VITRO	COUMARIN,4-PHENYL: 3'-5-DIHYDROXY-4'-7-DIMETHOXY:	ACTIVE

Citation 85123

Citation Details

Summary

Organisms and Their Experiments (1)

Exostema acuminatum (RUBIACEAE)

Show SPARQL Queries (1)

Query 1