Experiment 68743
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Theobroma cacao (STERCULIACEAE) |
| Citation | WAN,Y: VINSON,JA: ETHERTON,TD: PROCH,J: LAZARUS,SA: KRIS-ETHERTON,PM:. (2001). EFFECTS OF COCOA POWDER AND DARK CHOCOLATE ON LDL OXIDATIVE SUSCEPTIBILITY AND PROSTAGLANDIN CONCENTRATIONS IN HUMANS.. 74(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED, 2-PERIOD, CROSSOVER STUDY IN 23 HEALTHY SUBJECTS FED 2 DIETS. AN AVERAGE AMERICAN DIET (AAD) CONTROLLED FOR FIBER, CAFFEINE, AND THEOBROMINE AND AN AAD SUPPLEMENTED WITH 22 G COCOA POWDER AND 16 G DARK CHOCOLATE (CP-DC DIET), PROVIDING ~466 MG PROCYANIDINS/D. LDL OXIDATION LAG TIME WAS ~8% GREATER (P-0.01) AFTER THE CP-DC DIET HTAN AFTER THE AAD. SERUM TOTAL ANTIOXIDATN CAPACITY MEASURED BY OXYGEN RADICAL ABSORBANCE CAPACITY WAS ~4% GREATER (P-0.04) AFTER THE CP-DC DIET THAN AFTER THE AAD AND WAS POSITIVELY CORRELATED TITH LDL OXIDATION LAG TIME (R-0.32, P-0.02) THAN AFTER THE AAD; HOWEVER, LDL-HDL RATIOS WERE NIOT SIGNIFICANTLY DIFFERENT. TWENTY-FOUR-HOUR URINARY EXCRETION OF THROMBOXANE B2 AND 6-KETO- PROSTAGLANDIN F1A AND THE RATIO OF THE 2 COMPOUNDS WERE NOT SIGNIFICANTLY DIFFERENT BETWEEN THE 2 DIETS. COCOA POWDER AND DARK CHOCOLATE MAY FAVARABLY AFFECT CARDIOVASCULAR DISEASE RISK STATUS BY MODESTLY REDUCING LDL OXIDATION SUSCEPTIBILITY, INCREASING SERUM TOTAL ANTIOXIDANT CAPACITY AND HDL-CHOLESTEROL CONCENTRATIONS, AND NOT ADVERSELY AFFECTING PROSTAGLANDINS. |
| Dose amount | 22.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | SEEDS |
| Gender | GIVEN TO BOTH SEXES |