Citation 163284

HALL,IH: LIOU,YF: OKANO,M: LEE,KH:. (1982). ANTITUMOR AGENTS 46: IN VITRO EFFECTS OF ESTERS OF BRUSATOL,BISBRUSATOL,AND RELATED COMPOUNDS ON NUCLEIC ACID PROTEIN SYNTHESIS OF P-388 LYMPHOCYTIC LEUKEMIA CELLS.. 71()

Citation Details

TitleANTITUMOR AGENTS 46: IN VITRO EFFECTS OF ESTERS OF BRUSATOL,BISBRUSATOL,AND RELATED COMPOUNDS ON NUCLEIC ACID PROTEIN SYNTHESIS OF P-388 LYMPHOCYTIC LEUKEMIA CELLS.
AuthorsHALL,IH: LIOU,YF: OKANO,M: LEE,KH:
Year1982
Volume71
Issue

Summary

Year: 1982

Journal: Unknown

Organisms and Their Experiments (19)

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
WEAK ACTIVITY
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
WEAK ACTIVITY
3
DIHYDROFOLATE REDUCTASE INHIBITION
ACTIVE
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
ACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
INACTIVE
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
INACTIVE
9
ANTITUMOR ACTIVITY
INACTIVE
10
DNA SYNTHESIS INHIBITION
WEAK ACTIVITY
11
RNA SYNTHESIS INHIBITION
WEAK ACTIVITY
12
PROTEIN SYNTHESIS INHIBITION
ACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
ACTIVE
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
ACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
ACTIVE
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
ACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
INACTIVE
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
ACTIVE
10
DNA SYNTHESIS INHIBITION
ACTIVE
11
RNA SYNTHESIS INHIBITION
ACTIVE
12
PROTEIN SYNTHESIS INHIBITION
ACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
ACTIVE
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
ACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
ACTIVE
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
WEAK ACTIVITY
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
ACTIVE
10
DNA SYNTHESIS INHIBITION
ACTIVE
11
RNA SYNTHESIS INHIBITION
ACTIVE
12
PROTEIN SYNTHESIS INHIBITION
ACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
WEAK ACTIVITY
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
INACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
ACTIVE
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
ACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
INACTIVE
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
INACTIVE
9
ANTITUMOR ACTIVITY
INACTIVE
10
DNA SYNTHESIS INHIBITION
INACTIVE
11
RNA SYNTHESIS INHIBITION
INACTIVE
12
PROTEIN SYNTHESIS INHIBITION
INACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
WEAK ACTIVITY
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
WEAK ACTIVITY
3
DIHYDROFOLATE REDUCTASE INHIBITION
WEAK ACTIVITY
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
WEAK ACTIVITY
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
ACTIVE
10
DNA SYNTHESIS INHIBITION
INACTIVE
11
RNA SYNTHESIS INHIBITION
INACTIVE
12
PROTEIN SYNTHESIS INHIBITION
ACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
WEAK ACTIVITY
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
WEAK ACTIVITY
3
DIHYDROFOLATE REDUCTASE INHIBITION
WEAK ACTIVITY
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
ACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
ACTIVE
10
DNA SYNTHESIS INHIBITION
WEAK ACTIVITY
11
RNA SYNTHESIS INHIBITION
INACTIVE
12
PROTEIN SYNTHESIS INHIBITION
WEAK ACTIVITY

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
ACTIVE
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
ACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
WEAK ACTIVITY
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
ACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
ACTIN POLYMERIZATION INHIBITION
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
ACTIVE
10
DNA SYNTHESIS INHIBITION
ACTIVE
11
RNA SYNTHESIS INHIBITION
WEAK ACTIVITY
12
PROTEIN SYNTHESIS INHIBITION
ACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
INACTIVE
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
INACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
WEAK ACTIVITY
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
WEAK ACTIVITY
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
INACTIVE
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
INACTIVE
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
INACTIVE
9
ANTITUMOR ACTIVITY
INACTIVE
10
DNA SYNTHESIS INHIBITION
INACTIVE
11
RNA SYNTHESIS INHIBITION
INACTIVE
12
PROTEIN SYNTHESIS INHIBITION
WEAK ACTIVITY

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
ACTIVE
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
ACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
ACTIVE
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
ACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
ACTIVE
10
DNA SYNTHESIS INHIBITION
ACTIVE
11
RNA SYNTHESIS INHIBITION
ACTIVE
12
PROTEIN SYNTHESIS INHIBITION
ACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA SYNTHESIS INHIBITION
INACTIVE
2
RNA SYNTHESIS INHIBITION
WEAK ACTIVITY
3
PROTEIN SYNTHESIS INHIBITION
WEAK ACTIVITY
4
DNA POLYMERASE INHIBITION
INACTIVE
5
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
WEAK ACTIVITY
6
DIHYDROFOLATE REDUCTASE INHIBITION
WEAK ACTIVITY
7
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
WEAK ACTIVITY
8
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
9
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
INACTIVE
10
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
INACTIVE
11
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
INACTIVE
12
ANTITUMOR ACTIVITY
INACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
ACTIVE
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
ACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
WEAK ACTIVITY
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
ACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
ACTIVE
10
DNA SYNTHESIS INHIBITION
ACTIVE
11
RNA SYNTHESIS INHIBITION
ACTIVE
12
PROTEIN SYNTHESIS INHIBITION
ACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
ACTIVE
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
ACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
WEAK ACTIVITY
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
ACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
ACTIVE
10
DNA SYNTHESIS INHIBITION
ACTIVE
11
RNA SYNTHESIS INHIBITION
WEAK ACTIVITY
12
PROTEIN SYNTHESIS INHIBITION
ACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
WEAK ACTIVITY
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
ACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
ACTIVE
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
ACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
ACTIN POLYMERIZATION INHIBITION
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
ACTIVE
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
ACTIVE
10
DNA SYNTHESIS INHIBITION
ACTIVE
11
RNA SYNTHESIS INHIBITION
ACTIVE
12
PROTEIN SYNTHESIS INHIBITION
ACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
ACTIVE
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
ACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
ACTIVE
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
ACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
ACTIVE
10
DNA SYNTHESIS INHIBITION
ACTIVE
11
RNA SYNTHESIS INHIBITION
ACTIVE
12
PROTEIN SYNTHESIS INHIBITION
ACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
WEAK ACTIVITY
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
ACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
ACTIVE
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
ACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
ACTIVE
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
ACTIVE
10
DNA SYNTHESIS INHIBITION
WEAK ACTIVITY
11
RNA SYNTHESIS INHIBITION
WEAK ACTIVITY
12
PROTEIN SYNTHESIS INHIBITION
WEAK ACTIVITY

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
WEAK ACTIVITY
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
INACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
WEAK ACTIVITY
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
WEAK ACTIVITY
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
INACTIVE
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
INACTIVE
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
INACTIVE
9
ANTITUMOR ACTIVITY
INACTIVE
10
DNA SYNTHESIS INHIBITION
INACTIVE
11
RNA SYNTHESIS INHIBITION
WEAK ACTIVITY
12
PROTEIN SYNTHESIS INHIBITION
WEAK ACTIVITY

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
INACTIVE
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
INACTIVE
3
DIHYDROFOLATE REDUCTASE INHIBITION
WEAK ACTIVITY
4
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
WEAK ACTIVITY
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
6
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
8
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
9
ANTITUMOR ACTIVITY
INACTIVE
10
DNA SYNTHESIS INHIBITION
WEAK ACTIVITY
11
RNA SYNTHESIS INHIBITION
INACTIVE
12
PROTEIN SYNTHESIS INHIBITION
WEAK ACTIVITY

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
WEAK ACTIVITY
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
INACTIVE
3
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
WEAK ACTIVITY
4
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
6
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
WEAK ACTIVITY
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
8
ANTITUMOR ACTIVITY
ACTIVE
9
DNA SYNTHESIS INHIBITION
ACTIVE
10
RNA SYNTHESIS INHIBITION
WEAK ACTIVITY
11
PROTEIN SYNTHESIS INHIBITION
ACTIVE

Unknown organism

Experiment #Pharmacology TypeWorktypesCompoundResults
1
DNA POLYMERASE INHIBITION
WEAK ACTIVITY
2
FORMIC ACID INCORPORATION INTO PURINES INHIBITION
INACTIVE
3
PROTEIN SYNTHESIS INHIBITION DURING ELONGATION PROCESS
WEAK ACTIVITY
4
SUCCINATE DEHYDROGENASE INHIBITION(STATE 4)
INACTIVE
5
SUCCINATE DEHYDROGENASE INHIBITION(STATE 3)
INACTIVE
6
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 4)
INACTIVE
7
ALPHA-KETOGLUTARATE DEHYDROGENASE INHIBITION(STATE 3)
WEAK ACTIVITY
8
ANTITUMOR ACTIVITY
INACTIVE
9
DNA SYNTHESIS INHIBITION
WEAK ACTIVITY
10
RNA SYNTHESIS INHIBITION
INACTIVE
11
PROTEIN SYNTHESIS INHIBITION
WEAK ACTIVITY