Citation 60409

KEREKES,P: SHARMA,PN: BROSSI,A: CHIGNELL,CF: QUINN,FR:. (1985). SYNTHESIS AND BIOLOGICAL EFFECTS OF NOVEL THIOCOLCHICINES. 3. EVALUATION OF N-ACYLDEACETYLTHIOCOLCHICINES, N-(ALKOXYCARBONYL) DEACETYLTHIOCOLCHICINES, AND O-ETHYLDEMETHYLTHIOCOLCHICINES. NEW SYNTHESIS OF THIODEMECOLCINE AND ANTILEUKEMIC EFFECTS OF 2-. 28(9)

Citation Details

Title	SYNTHESIS AND BIOLOGICAL EFFECTS OF NOVEL THIOCOLCHICINES. 3. EVALUATION OF N-ACYLDEACETYLTHIOCOLCHICINES, N-(ALKOXYCARBONYL) DEACETYLTHIOCOLCHICINES, AND O-ETHYLDEMETHYLTHIOCOLCHICINES. NEW SYNTHESIS OF THIODEMECOLCINE AND ANTILEUKEMIC EFFECTS OF 2-
Authors	KEREKES,P: SHARMA,PN: BROSSI,A: CHIGNELL,CF: QUINN,FR:
Year	1985
Volume	28
Issue	9

Summary

Year: 1985

Journal: Unknown

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	SYNTHESIS OF ANALOGS	COLCHICINE	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	COLCHICINE	.
5	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE	ACTIVE
6	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE	ACTIVE
7	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	SYNTHESIS OF ANALOGS	THIOCOLCHICINE	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIOCOLCHICINE	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIOCOLCHICINE	.
5	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE	ACTIVE
6	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIOCOLCHICINE,2-DEMETHYL:	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,2-DEMETHYL:	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIOCOLCHICINE,2-DEMETHYL:	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIOCOLCHICINE,2-DEMETHYL:	.

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	COLCHICINE,3-DEMETHYL: THIO:	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,3-DEMETHYL: THIO:	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	COLCHICINE,3-DEMETHYL: THIO:	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	COLCHICINE,3-DEMETHYL: THIO:	.
5	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,3-DEMETHYL: THIO:	ACTIVE
6	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,3-DEMETHYL: THIO:	ACTIVE
7	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,3-DEMETHYL: THIO:	ACTIVE
8	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	COLCHICINE,3-DEMETHYL: THIO:	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIOCOLCHICINE,DEACETYL: N-BENZOYL:	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,DEACETYL: N-BENZOYL:	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIOCOLCHICINE,DEACETYL: N-BENZOYL:	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIOCOLCHICINE,DEACETYL: N-BENZOYL:	.

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIOCOLCHICINE,DEACETYL: N-BUTYRYL:	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,DEACETYL: N-BUTYRYL:	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIOCOLCHICINE,DEACETYL: N-BUTYRYL:	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIOCOLCHICINE,DEACETYL: N-(ETHOXY-ACETYL):	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,DEACETYL: N-(ETHOXY-ACETYL):	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIOCOLCHICINE,DEACETYL: N-(ETHOXY-ACETYL):	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIOCOLCHICINE,DEACETYL: N-(ETHOXY-ACETYL):	.

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIOCOLCHICINE,DEACETYL: N-(TRIFLUORO-ACETYL):	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,DEACETYL: N-(TRIFLUORO-ACETYL):	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIOCOLCHICINE,DEACETYL: N-(TRIFLUORO-ACETYL):	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIOCOLCHICINE,DEACETYL: N-(TRIFLUORO-ACETYL):	.

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIOCOLCHICINE,N-(FORMYL-DEACETYL):	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,N-(FORMYL-DEACETYL):	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIOCOLCHICINE,N-(FORMYL-DEACETYL):	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIOCOLCHICINE,N-(FORMYL-DEACETYL):	.

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIOCOLCHICINE,DEACETYL: N-(ETHOXY-CARBONYL):	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,DEACETYL: N-(ETHOXY-CARBONYL):	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIOCOLCHICINE,DEACETYL: N-(ETHOXY-CARBONYL):	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIOCOLCHICINE,DEACETYL: N-(ETHOXY-CARBONYL):	.
5	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,DEACETYL: N-(ETHOXY-CARBONYL):	ACTIVE
6	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,DEACETYL: N-(ETHOXY-CARBONYL):	ACTIVE
7	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,DEACETYL: N-(ETHOXY-CARBONYL):	ACTIVE

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIOCOLCHICINE,DEACETYL: N-(PHENOXY-CARBONYL):	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,DEACETYL: N-(PHENOXY-CARBONYL):	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIOCOLCHICINE,DEACETYL: N-(PHENOXY-CARBONYL):	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIOCOLCHICINE,DEACETYL: N-(PHENOXY-CARBONYL):	.

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIOCOLCHICINE,DEACETYL: N-(BUTOXY-CARBONYL):	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,DEACETYL: N-(BUTOXY-CARBONYL):	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIOCOLCHICINE,DEACETYL: N-(BUTOXY-CARBONYL):	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIOCOLCHICINE,DEACETYL: N-(BUTOXY-CARBONYL):	.

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIOCOLCHICINE,DEACETYL: N-((VINYL-OXY)-CARBONYL):	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIOCOLCHICINE,DEACETYL: N-((VINYL-OXY)-CARBONYL):	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIOCOLCHICINE,DEACETYL: N-((VINYL-OXY)-CARBONYL):	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIOCOLCHICINE,DEACETYL: N-((VINYL-OXY)-CARBONYL):	.

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIODEMECOLCINE,N-(TRIFLUORO-ACETYL):	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIODEMECOLCINE,N-(TRIFLUORO-ACETYL):	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIODEMECOLCINE,N-(TRIFLUORO-ACETYL):	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIODEMECOLCINE,N-(TRIFLUORO-ACETYL):	.

Experiment #	Pharmacology Type	Worktypes	Compound	Results
1	Not specified	COMPLETE SYNTHESIS REPORTED	THIODEMECOLCINE	None
2	ANTITUMOR ACTIVITY	PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODE	THIODEMECOLCINE	ACTIVE
3	TUBULIN BINDING EFFECT	PHARMACOLOGY OF COMPOUND - IN VITRO	THIODEMECOLCINE	ACTIVE
4	TOXICITY ASSESSMENT(QUANTITATIVE)	TOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VIVO	THIODEMECOLCINE	.

Citation 60409

Citation Details

Summary

Organisms and Their Experiments (17)

Query 1